TRT Cream vs Injections: Making the Right Treatment Choice

Men with low testosterone or testosterone deficiency can restore their testosterone levels with testosterone replacement therapy (TRT). Lower libido, persistent fatigue, irritability, and inexplicable weight gain are some of the symptoms that may manifest with this condition.

While aging causes testosterone levels to naturally drop, some men experience intense fluctuations. These fluctuations can cause symptoms that negatively impact their quality of life. In these situations, doctors might consider testosterone therapy.

Among the various forms of testosterone, doctors frequently recommend injections and creams. Being aware of the advantages and disadvantages of each type of therapy will help you decide the best treatment plan for you.

Key Takeaways

• TRT creams and injections are two of the most common and effective options for testosterone therapy.
• Testosterone creams deliver a steady dose of hormone through the skin and are ideal for those who prefer non-invasive, daily applications.
• Biweekly testosterone injections are suitable for individuals who prefer less frequent injections, despite their invasive nature.
• Both treatments are clinically proven to improve symptoms of low testosterone.
• Your choice should factor in your lifestyle and ability to adhere to dosing schedules.
• Skin reactions are common with creams, while injections tend to cause site-specific discomfort and hormone fluctuations.

How Testosterone Creams Work

Testosterone creams are a form of topical application that delivers the hormone transdermally (through the skin). This method allows your body to absorb the hormone slowly into the bloodstream.

Testosterone creams mimic the body’s natural rhythm of testosterone production. This provides a gradual release throughout the day.

Unlike oral testosterone, which can strain the liver, transdermal applications bypass the liver entirely. This improves absorption and minimizes side effects to the liver.

Doctors often prescribe the creams for daily use and instruct patients to apply them to clean, dry skin. You should wait for the product to absorb fully before allowing your skin to come into contact with clothing.

You can apply testosterone gel and cream to your inner thighs, shoulders, upper arms, or abdomen. These are areas that are less likely to come into contact with other people.

The appeal of testosterone cream lies largely in its ease of use and non-invasive nature. For men who dislike needles or those managing concurrent conditions that require regular topical medication, this mode of delivery can be practical.

Effectiveness of TRT Creams

Clinical studies show that testosterone creams can normalize serum testosterone levels in men with low testosterone. Men undergoing testosterone replacement therapy (TRT) with transdermal creams have reported increased muscle mass and improved mood and libido.

A 2018 study in the Journal of Clinical Endocrinology & Metabolism reported improvements in free testosterone, sexual function, and energy levels among men using daily testosterone gel and cream regimens.

Differences in skin thickness and hydration levels can influence how well the cream is absorbed. Adherence makes a difference to their effectiveness; missed applications or improper technique can lead to inconsistent hormone levels.

Safety Precautions When Using Testosterone Cream

Use testosterone creams only under strict medical supervision, and apply them carefully to prevent accidentally transferring them to children or pets.

To manage this risk, allow the cream to dry completely and cover the application area with clothing.

Furthermore, make sure you store your testosterone cream out of reach of others and mark the container. If you experience skin irritation, stop using the cream and contact a medical professional.

Understanding TRT Injections

You can have testosterone injections on a weekly or biweekly basis. TRT injections, such as testosterone enanthate and testosterone cypionate, can be injected into a muscle (intramuscularly) or just below the skin (subcutaneously).

Testosterone injections are a popular way to administer the hormone because they provide predictable results. They increase testosterone levels quickly, making them ideal for men who need relief from low testosterone symptoms.

They have a long half-life, so a weekly or biweekly dose is effective for most men.

This method of delivery is ideal for men who don't want to manage their testosterone levels daily. You can decide if you would prefer to self-inject or visit your healthcare provider or clinic.

Effectiveness of Testosterone Injections

Your body absorbs injectable testosterone, like testosterone enanthate, directly into the bloodstream, avoiding the absorption variability that can happen with topical creams. This direct delivery makes it highly bioavailable.

Men who inject testosterone report improvements in their sexual health (including erectile functionality) and mood stability.

A review published in Andrology reported that men on testosterone treatment with testosterone cypionate showed higher testosterone levels and fewer depressive symptoms when compared to baseline.

Despite its effectiveness, injectable testosterone can cause hormone fluctuations if it is not administered at the appropriate time intervals. Peaks and troughs in testosterone can negatively affect your mood and energy levels. A tailored dosing schedule based on your metabolic needs is the best way to circumvent this problem.

Safety Precautions When Using Testosterone Injections

Testosterone injections generally remain safe when doctors supervise their use, but they still carry certain risks. Maintaining good hygiene and changing injection sites can help you avoid redness and swelling.

TRT Cream vs Injections: Lifestyle Considerations for Low Testosterone

Choosing the right way to administer testosterone replacement therapy largely comes down to your lifestyle. If you have a demanding or unpredictable schedule, applying cream every day may not be the most practical option.

You can administer testosterone injections yourself weekly or biweekly, which may better suit your routine. However, some people have a phobia of needles or do not want to self-inject. If you prefer, you can visit a healthcare provider for the injections.

When you use testosterone gel, cream, or injections to treat low testosterone, your healthcare provider should order regular bloodwork to monitor your hormone and PSA levels. You should also attend routine medical checkups to ensure your dosage remains appropriate and effective.

Ultimately, your preferences and need for convenience will determine the method of delivery best suited to you.

Potential Side Effects

Both delivery methods have similar side effects; however, the intensity can vary.

• TRT Creams: Most commonly, TRT creams can cause reactions on the skin. These include redness, swelling, itching, and dermatitis.
• TRT Injections: TRT injections can cause swelling and pain at the injection site. Mistimed injections can cause spikes in testosterone levels, leading to water retention and mood swings in some cases.

References

1. Journal of Clinical Endocrinology & Metabolism, 2018. "Clinical outcomes of testosterone therapy via topical application."

2. Andrology, 2020. "Long-term effects of testosterone cypionate injections on hormonal and psychological health."

3. Mayo Clinic. "Testosterone therapy: Potential benefits and risks as you age."

4. Harvard Health Publishing. "Testosterone therapy: Key considerations for aging men."

5. American Urological Association. "Evaluation and Management of Testosterone Deficiency."